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KMID : 0369820050350060403
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 6 p.403 ~ p.409
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Transdermal Delivery of FITC-Ovalbumin with Microneedle System
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장우영/Jang WY
이창래/서성미/이봉/김문석/강길선/이한구/이해방/Lee CR/Seo SM/Lee B/Kim MS/Khang GS/Lee HG/Lee HB
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Abstract
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For transdermal delivery of large molecular drugs such as vaccine and protein drugs, novel microneedle treatment device with roll was designed. The roll dimension is 1.43 cm diameter and 2.8 cm perimeter. Total number of microneedle on the roll is 3,360 with 230μm height and 740μm distance. The pore with 150μm depth and 35μm diameter on the skin was made by the designed microneedle device. This system could be achieved without pain. The permeation rates of FITC labelled ovalbumin (FITC-OVA, molecular weight: 45,000 g/mol) as a model protein were determined by modified Franz diffusion cells using skins of hairless mice or SD rats which were treated by using microneedle device two or four times. The average penetration fluxes of model protein increased from 674 to 872μg/cm2?hr as the number of treatment to make pore increased from two to four times. In conclusion, we confirmed the possibility of using the designed microneedle treatment device for transdermal delivery of the large molecular drugs.
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KEYWORD
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OVA, FITC, Transdermal, DDS, Microneedle system
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